Platelets interacting with and binding to other platelets is referred to as?

Platelets interacting with and binding to other platelets is referred to as?

• A. Adhesion
• B. Aggregation
• C. Release
• D. Retraction

Answer: (B)

Aggregation is the process by which platelets bind to and stick to each other to form the initial platelet plug. After platelets are activated by contact with damaged vessel walls, they express GPIIb/IIIa receptors that bind fibrinogen, which acts as a bridge linking adjacent platelets. This collective sticking together creates a loose, mobile plug essential for stopping bleeding. This step is distinct from adhesion, where platelets attach to exposed subendothelial surfaces (like collagen) via von Willebrand factor, and from release, the secretion of granule contents that amplify activation, or from retraction, the later tightening of the clot as platelets contract. So the described interaction specifically describes aggregation.

Aggregation is the process by which platelets bind to and stick to each other to form the initial platelet plug. After platelets are activated by contact with damaged vessel walls, they express GPIIb/IIIa receptors that bind fibrinogen, which acts as a bridge linking adjacent platelets. This collective sticking together creates a loose, mobile plug essential for stopping bleeding. This step is distinct from adhesion, where platelets attach to exposed subendothelial surfaces (like collagen) via von Willebrand factor, and from release, the secretion of granule contents that amplify activation, or from retraction, the later tightening of the clot as platelets contract. So the described interaction specifically describes aggregation.